Immolation starts where Triple Point ends, the crew witnessing the launching of hybrid pods from Io. Alex does what desparate little he can to destroy the hybrids pods with the Rocinante but, soon the Rocinante runs out of ammunition. One hybrid pod is deflected by his PDCs, spiralling until it collides with the Agatha King. The rest of the Rocinante crew on Io, enter the research base Prospero Station. In an act to slow down the Rocinante crew Jules-Pierre Mao commands what remaining staff he has to engage the Martian assault force while Strickland regretfully releases the hybridized Katoa. Soon, the Rocinante crew runs into Jules-Pierre's staff guarding the door. Under fire, Bobbie calmly walks into the passage way. In her power armor, she assesses the targets and quickly kills Jules-Pierre's staff with short gun bursts from power armor's gun. Moving forward they spot the Hybrid in the distance. Bobbie decides the best action is to distract hybrid, so she runs forward, shoots the hybrid and escapes through a hatch, out onto the surface Io.
On the damaged Agatha King, the protomolecule quickly infects a majority of crew, turning them into hostile zombies. The protomolecule, in a change from the past, appears to consume the ship itself as part of the protomolecule organism. Cotyar, who is still on the Agatha King, floating in the med bay, when Ensign Larson, who is part of the Agatha King crew, enters the med bay while being chased by a lieutenant who has been infected by the protomolecule. Larson shoots the crazed zombie crewman dead but, without any protection, she has touched the protomolecule, which Cotyar explains is a death sentence. Larson frees Cotyar, admitting she has no idea what cause she is fighting for. Cotyar, before leaving the med bay, puts on a vac suit.
Back on Io, with some camera feeds available, Holden can direct Amos and Prax to the children, who may be evacuated by Strickland, before they can be rescued. Holden delays Strickland by evacuating the air in the shuttle bay. While observing the camera feeds, Holden sees Jules-Pierre on Io in the base. He leaves to pursue Jules-Pierre. Before Amos and Prax get to Strickland and the kids, Strickland puts the kids in a air lock. Then, Strickland shoots and kills the nurse with him. When Amos and Prax arrive, Strickland says the nurse was going kill all the children and he saved them before recognizing Prax. Prax demands the location of Mei, which Strickland acquiesces by opening the air lock. Prax hugs Mei then introduces Amos as his best friend and instructs her to go with him. Prax walks over to Strickland determined to kill him but, at the last second, Amos intercedes, saying he’s not "that guy", the guy that kills. Strickland proceeds to thank Amos as Prax leaves but Amos turns to face Strickland with an expression that emphasizes the words he says, "I am that guy." Amos closes the door to the air lock and shoots Strickland with his shotgun. Amos, Prax, Mei and three other children leave and return to the Rocinante. During this, Holden intercepts Jules-Pierre, shoots his guard and take Jules-Pierre captive.
Bobbie who has been in a shoot and run battle with the hybrid is caught off guard by it. The hybrid tackles Bobbie over a ledge down to the ground. Before critically damaging Bobbie, Bobbies power armor begins to lose power, flashing low battery. While the Hybrid is distracted by something in the distant heavens, Bobbie without help from the suit manages to raise her gun to the rear part hybrid's head and unleashes the remaining ammo she has. The hybrid, missing part of his head rolls over and expires.
Alex and Naomi, begin realizing the magnitude of events happening on the Agatha King. Firstly, the hybrid missiles launched at Mars which have gone black, secondly, the control of those hybrid pods is aboard the A.K. and most troublingly, the protomolecule taking over the ship. They use the Razorback so they can access a utility hatch on the Agatha King in an attempt to stop the hybrid pods. When they enter the Agatha King's CIC, they find Admiral Nguyễn dying in his chair. Naomi attempts to disable the hybrid missiles, when they receive a video transmission. Cotyar, who has been infected by the protomolecule by this point, is in the reactor room, disabling magnetic control rods containing the fusion reactor. He broadcasts to all ships in the area, unaware who is watching, that he is setting up the reactor to detonate and to eliminate the threat of the protomolecule-infested UNN flagship. In a final farewell, Cotyar expresses solace in repaying his obligation to Charanpal. Naomi and Alex, aboard the Razorback quickly move away the Agatha King, which blows up in the back ground.
On Earth, the UN Headquarters has been anxiously wrestling to decipher events around Jupiter, the light delay between Jupiter and Earth is around 40 minutes. Anna in her parting act gives Esteban the incriminating speech Errinwright gave which triggered the current war. The Secretary-General uses this information to arrest Errinwright, which will exonerate himself from the millions of lives lost.
On the Rocinante, Alex helps Bobbie into the med bay. Naomi and Holden, in bed together are reconciling; however, they recognize that Naomi is on a path that will take her away from the Roci. Amos who is feeding the kids in the galley, catches news of Venus. There, a giant protomolecule object ascends through the atmosphere and appears to be moving away from the planet, unfolding tentacle-like appendages.
- Steven Strait as James Holden
- Cas Anvar as Alex Kamal
- Dominique Tipper as Naomi Nagata
- Wes Chatham as Amos Burton
- Frankie Adams as Bobbie Draper
- Shawn Doyle as Sadavir Errinwright
- Shohreh Aghdashloo as Chrisjen Avasarala
- Chad L. Coleman as Fred Johnson
- Terry Chen as Praxideke Meng
- Nick E. Tarabay as Cotyar Ghazi
- François Chau as Jules-Pierre Mao
- Byron Mann as Admiral Augusto Nguyễn
- Ted Atherton as Lawrence Strickland
- Elizabeth Mitchell as Anna Volovodov
- Jonathan Whittaker as Sec-Gen Gillis
- Jordan Dacol as Katoa (Hybrid)
- Leah Jung as Mei
- Martin Roach as Admiral Souther (credit only)
- Michael Brown as Lt. Lipson
- Nicole Stamp as Medical Tech
- Nolan Greenwald as Mao Bodyguard #2
- Ryan Maramieri as Prospero Child
- Sydney Meyer as Ensign Larson
- Tyler Blake Smith as Mao Bodyguard #1
- Elias Toufexis as Mocap. Monster (motion capture)
- This episode marks the end of Caliban's War.